Function: Transmit message to muscles Motor neurone disease is a group of diseases which affect the motor neurons and usually occurs among adults. The ratio of male to female is 1.8:1 Average age: 50-60 Unknown Degenerative motor neurone Viral infection Inherited Muscular atrophy Stiff-muscles or numbess Increased muscle tone Convulsion The respiratory muscles will be affected in serve cases, leading to difficulty in speech or swallowing, or even death Motor Neurone Disease is classified into different types depending on the area affected: Motor neuron disease with only lower motor neuron signs Patients display progressive weakness that can be rapidly progressive or very slow atrophic muscles are always noticed absence of brisk reflexes The prognosis is better than other type of motor neuron disease Lower motor neuron deterioration Difficulty swallowing, speaking, chewing and breathing The prognosis is usually the worst among motor neuron disease The most common form of motor neuron disease Both the upper motor neurons and the lower motor neurons degenerate or die, ceasing to send messages to muscles The muscles gradually weaken, waste away (atrophy), and twitch (fasciculations) . Eventually, the ability of the brain to start and control voluntary movement is lost It is a rapidly progressive, invariably fatal neurological disease. Patient may die within 2 to 3 years The patient cannot performed at least 3 activities of daily livings without assistance: Bathing Changing clothes Toileting Eating Get off from bed or chair No curing method There are medications to decrease the extent of muscle atrophy, secretions or shortness of breath etc. Instruments or tools to improve respiratory or speech problems Physiotherapy Occupational therapy Speech therapy Dietitians