Kidneys failed to function properly Waste products and excess fluid cannot be removed from the body Disease originated in kidneys itself disease originated in organs other then the kidneys. For example, liver cirrhosis, heart disorders and lunch problems etc Medications disorders originated in parts after the blood leaves the kidneys. For example, enlarged prostate, kidney stones, tumors of the bladder or pelvis etc. Disease originated in kidneys itself Congenital renal disease Other disease: diabetes, SLE and gout Unexplained weight changes Generalized swelling of the body Increasing fatigue and tiredness nausea, vomit, headache increase in blood pressure decreased urine output Coma Medication therapy Renal dialysis, including: - Haemodialysis - Peritoneal dialysis Diet control Renal transplantation