There are fluid-filled sacs or cysts form in the medulla region of both kidneys and involving the collecting ducts. The kidneys will become very large and the kidney functin will be impaired. An inherited disease and usually occurs in adults at age 20s There are 3 types of medullary cystic disease: Infantile: median ages of onset is usually 1-3 years Juvenile : median ages of onset is usually 13 years Adolescent: median ages of onset is usually 19 years Proteinuria,haematuria and progressive renal failure Urinary tract infection Hypertension Decreased renal function Renal failure Diet control Renal dialysis Renal transplantation